Preimplantation genetic diagnosis (PGD)

If, based on the history obtained during genetic counseling, family tree analysis, and the results of previous genetic tests conducted on samples of affected individuals and other family members, the couple is diagnosed as being at risk of having a child with a genetic disorder. It is possible to carry out a genetic examination by the method of pre-implantation genetic diagnosis (PGD).

In this method, pregnancy occurs using the reproductive technology of ectopic or laboratory fertilization, and at a certain stage of embryo development in the laboratory, sampling or biopsy of the embryos is performed by separating one or more cells from the embryos. And the genetic investigation is done on these cells in terms of previously known mutation. In the next step, the embryos that have been diagnosed as healthy in terms of the investigated mutation are transferred to the mother's womb.

Benefits of PGD method:

Because diagnostic examinations are performed before the embryos are transferred to the mother's womb if the mother becomes pregnant, there is a high probability that the pregnancy will occur with a healthy fetus, and the probability of needing to terminate the pregnancy is less.

Disadvantages of PGD method:

Despite the high accuracy of this test, this accuracy rate is not 100% and it is still necessary to perform PND during pregnancy to ensure the health status of the fetus.

The cost of these methods is very high.

The success of the mother's pregnancy depends on the techniques used, about 30% in each repeated cycle of IVF.